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Neuron:纪如荣团队揭示免疫抑制分子PD-1调控海马突触可塑性和学习 ...
程序性细胞死亡蛋白1 (PD-1,由Pdcd1基因编码),又称CD279,作为免疫检查点调节剂,可下调免疫系统并抑制T细胞活性,是癌症免疫治疗的主要靶点。PD-1广泛表达在T细胞、巨噬细胞、小胶质细胞和黑色素瘤细胞。 最近研究表明PD-1也参与调控中枢神经系统:在阿尔 ...
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