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Br J Pharmacol:一种新型ryanodine受体2抑制剂M201-A,增强尿钠、肾功能和 ...
该研究表明新型药物M201-A通过RyR2抑制舒张Ca2+泄漏,改善大鼠心脏lusii -inotropic效应,并增强人的尿钠和肾功能,从而为慢性肾脏疾病和心力衰竭提供一种潜在的新治疗选择。 慢性肾脏疾病(CKD)是一个重大的全球公共卫生问题,全球估计有7亿人患病。相反 ...
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