Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic ...

在这项研究中，研究人员表明，DNA断裂在修复后的基因组位点上留下了长期的标记，这破坏了大染色质邻域的三维排列，持续了几轮连续的细胞分裂，并引发了基因表达的遗传性改变，即使原发性DNA损伤被完全修复。该研究将这种现象称为染色质疲劳，并提出它代表了迄今为 ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

A double-strand break (DSB) is a type of DNA damage where both strands of the DNA helix are cut or broken at the same location, causing a complete discontinuity in the DNA molecule. Unrepaired or ...

New research sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human cells. The study demonstrates how these proteins ...